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March 2016

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An explorative essay: Can magnesium chloride raise seizure threshold?

Exploiting ionic changes in the epileptic brain to increase seizure threshold with oral supplementation of magnesium chloride Epilepsy is a serious neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, associated with abnormal electrical activity in the brain. Seizures are associated with neuronal ionic changes (Schwartzkroin, 1998) that can be managed with increased efficacy through magnesium chloride supplementation. Magnesium supplementation should be part of an essential component of a management strategy for any type of epilepsy to raise seizure threshold and maintain trace element homeostasis. The form of magnesium that has been used most clinically and has the longest therapeutic use to treat epilepsy in the literature is magnesium sulphate, however this is not practical or convenient for patients with epilepsy. While there needs to be more research into other forms of magnesium to manage epilepsy, there remains adequate evidence to suggest that oral magnesium, particularly magnesium chloride, has numerous benefits to increase seizure threshold by modulating neuronal activity. Magnesium chloride is easy to ingest, convenient to apply, acts effectively as a central nervous system depressant, improves insulin sensitivity, and lowers plasma blood glucose. This essay will explain how these mechanisms can effectively contribute towards raising seizure threshold for patients with all types of epilepsy. ‘Non-synaptic mechanisms’ are an important consideration in an attempt to manage neuronal activity in epilepsy. This includes, but is not exclusive to ionic interactions that involve magnesium, potassium, sodium and calcium. Increases in the extracellular concentration of potassium in particular is of vital importance in order to consistently manage epileptic seizures however this is dependent on many cofactors. Magnesium is involved with over 300 enzymatic reactions and has numerous mechanisms of action that make it an effective standalone treatment to modulate neuronal excitability with great efficacy and safety. ‘Regulation…

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Optogenetics and cancer?

My life is already becoming much more productive and enjoyable since making alterations to my light environment. I feel the benefits going forward as I learn and apply more could play a significant role in optimising this metabolic approach to my situation.   I am undertaking a great deal of study into the potential of optogenetics for a variety of applications and would love to take this further as I progress at university. Ontogenetics has roles to play in glucose regulation, behaviour, and several other hormonal actions as well as having the potential to treat blindness and diseases relating to the eye. I have attached a number of links I find incredibly interesting to the Youtube video and I hope others share my enthusiasm for this approach in clinical settings to treat neurological disease. If you’re too lazy to look for the links here they are! Optogenetics and its potential for neurological disease management: optogenetics news story- http://www.engadget.com/2016/03/20/optogenetics-gets-first-human-patient/ optogenetics and glucose metabolism- http://www.pnas.org/content/early/2016/03/16/1521160113 optogenetics- http://www.annualreviews.org/eprint/SFGyCTHrhPkwghr3txaY/full/10.1146/annurev-neuro-061010-113817 optogenetics and disease, mental health- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735812/ http://www.sciencedirect.com/science/article/pii/S0896627315011666 http://www.nature.com/nature/journal/v531/n7595/full/nature17172.html McCullum lake cancer cluster- http://www.chicagotribune.com/news/ct-cancer-cluster-settlement-met-20141230-story.html melatonin and cancer- http://link.springer.com/chapter/10.1007/978-3-642-59512-7_27#page-1

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Think it’s all about food? Think again.

I’m collecting more information on how I can improve my light environment, this is pretty good.  Astrocytes are like many little clocks, mess up the times and it can change your genes. I was diagnosed with an astrocytoma so this information is gold.  Light is often more important than food, I understand this. The problem is probably that people can’t make much money out of this and it’s not trendy.  http://youtu.be/CEEzydHmcJ8

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