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April 2016

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Promoting autophagy with the aid of periodic, habitual therapeutic fasting for brain cancer management

I am inclined to conclude that the studies presented here in relation to fasting and autophagy provide sufficient evidence to support a key aspect of my metabolic strategy to manage brain cancer.... and no, its not just because I am biased. ;-) I have been experimenting with personalised fasting protocols lately, allowing for what I feel could be a theoretically viable symbiotic relationship of periodic, habitual therapeutic fasting + complimentary dose specific supplementation of fish oils + salt preparations + magnesium chloride supplementation as a specific, targeted, individualistic approach. I base this approach on my exhaustive research undertaken over the years following my diagnosis, scrutinising decades of evidence based, peer reviewed research to falsify or validate my hypotheses. I will attempt to explain why and how I believe implementation of such an approach could yield positive results for my n=1 experiment: Numerous individuals have queried my dietary protocol, however it could reasonably be postulated, based on the evidence and underlying physiological mechanisms of this type of dietary manipulation, that the most significant benefits would likely come from calorie restriction and fasting. The metabolic state prior to commencement of a fast and personal dietary choices upon completion of such endeavours are undoubtedly of vital importance of course so as to not raise IGF-1 and upregulate mTOR during the re-feeding phase. The gut microbiota before, during, and after fasting is another subject of great interest to me but I won't go into that because it is fairly complicated territory to cross over and I don't have time to talk about the trillions of bacteria involved despite it being critical to all aspects of health and all life on this planet as we know it... primordial poop and all that jazz. Back to autophagy, fasting, and re-feeding.... Growth factors must be regulated via continued... Continue reading
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More thoughts, experiments and investigations on curcumin in vivo

Following on from my last post, I have been questioning myself more about optimal dosages for supplementation of curcumin, particularly in light of such studies whereby ‘high’ amounts of the compound are tolerated with minimal to zero toxicity reported. One particular study caught my eye. ‘A dose escalation study was conducted to determine the maximum tolerated dose and safety of a single dose of standardized powder extract, uniformly milled curcumin (C3 Complex™, Sabinsa Corporation). Healthy volunteers were administered escalating doses from 500 to 12,000 mg.’ http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-6-1012,000 mg is a lot considering I take 1,500 mg per day which I deem to be the optimal therapeutic dose for me as an individual. There may be situations by which higher doses may be more beneficial though I believe the dosages I maintain at the moment should be adequate for my current aims. The results of the study revealed some thought provoking findings though I dd wonder about the 17 participants that did experience issues:‘Seven of twenty-four subjects (30%) experienced only minimal toxicity that did not appear to be dose-related. No curcumin was detected in the serum of subjects administered 500, 1,000, 2,000, 4,000, 6,000 or 8,000 mg. Low levels of curcumin were detected in two subjects administered 10,000 or 12,000 mg.’The study goes on to say that ‘no toxicity appeared to be dose related’, indicating that of those 17 participants there may have been extraneous factors or sensitivities to the curcuminoid formulation regardless of the dose ingested. I also believe that because the trial was looking at a single, oral dose of this formulation, it may have been enough to explain some of these mild, adverse effects. Nevertheless, they concluded that ,’The tolerance of curcumin in high single oral doses appears to be excellent.’ Given the relatively very high doses used in the study on the whole…

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Curcumin: Problems and promises

I take curcumin regularly. This is a nice visual representation of how it potentially acts as an anti-cancer agent providing all conditions requiring therapeutic efficacy are met. http://hrjournal.net/article/view/1325 Bioavailability is key here to make the most of the therapeutic benefits of curcumin. If you take it as a supplement make sure it is paired with piperine and is taken in therapeutic doses. We need more in vivo studies in brain tumour patients to elucidate what would act as an optimal dose, crossing the blood brain barrier so I will continue to research this medicinal compound.  ‘Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipid complex; and fifth, the use of structural analogues of curcumin (e.g., EF-24). The latter has been reported to have a rapid absorption with a peak plasma half-life. Despite the lower bioavailability, therapeutic efficacy of curcumin against various human diseases, including cancer, cardiovascular diseases, diabetes, arthritis, neurological diseases and Crohnʼs disease, has been documented. Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.’  http://pubs.acs.org/doi/abs/10.1021/mp700113r As the acclaimed philosopher Karl Popper explained, a good scientist should constantly be trying to prove themselves wrong in order to have a truly unbiased opinion. This forms the basis of pure, valid, reliable scientific research. http://natm.wikia.com/wiki/The_Thinker If I am trying to prove myself right all the time without a healthy degree of skepticism I may ignore the challenges…

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