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July 2016

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New insights from a new website?

I have created a website to provide a place to share data I have collected to support a metabolic protocol to managing brain cancer. I hope that this information can empower patients by providing the resources they need to take control of their treatment, whatever that may be. I have decided to name it: ‘Metabolic Therapy Resources for Brain Cancer Management’ This website will grow and evolve as I gather more information and when I have time to update it. Feel free to contribute with additional materials others might find useful in their search for evidence based metabolic approaches to this devastating disease. Please share with anybody you know who has been diagnosed with a brain tumour of any grade and type. http://www.braincanceroptions.com

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Fatty acids and brain tumours

After a recent study came out suggesting that brain tumours can adapt and use fatty acids for energy I thought I would attempt to clear up a few things concisely and succinctly. I’m writing a research proposal at the moment that I’m very excited about if my plans ever come to fruition from sufficient funds but firstly I wanted to tackle this confusion over the fatty acid study that came out recently entitled; ‘Fatty acid oxidation is required for the respiration and proliferationof malignant glioma cells.’ Firstly I would like to point out that the title is a misleading half truth which validates one very important point but does by no means conclude that all fats are created equal. I could point out several questionable aspects of the study design, however I cannot fault the actual investigation, more the application and the sweeping conclusions made that I find a little irresponsible and misleading. The conclusions by no way invalidate a ketogenic diet, but the findings definitely support a well structured ketogenic diet and validate the significant benefits that come with ensuring fatty acids are balanced appropriately. I found some of the conclusions equally baffling, including this one. Also strangely no real mention of glutamine even though one of the study aims was to identify the metabolic fuel requirements of human glioma cells.: They mention how the fatty acid binding drug etomoxir can be used therapeutically to inhibit fatty acid oxidation and reduce proliferation and viability of mouse glioma-initiating cells which is certainly an interesting finding and I applaud them for that, however I question the safety of this drug in terms of the detrimental effect is has on the liver over time and the possible depletion of DHA which I will explain has countless anti tumour benefits. The drug could potentially…

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Gliomas adapting to using fats for energy?

Brain tumours adapting to fats? The papers at the bottom of this page will go some way to allay any fears you may have. It underlines my approach of balancing out my fatty acids and testing through http://www.omegaquant.com/ every 3-6 months to examine my fatty acid profile via a blood sample. If you have brain cancer I believe this is the most important test you can have.  The ratio of omega 3 and 6 is of vital importance. This is more important than simply monitoring ketosis and it compliments ketogenesis nicely. Brains want lots of DHA, especially brain afflicted with any kind of neurogenerate be disease.  http://www.graduate-studies-in-cancer-research.org/Godbout/pdfs/Final%20with%20audio.pdf ‘The fatty acid composition of human gliomas differs from that found in non-malignant brain tissue.’ http://link.springer.com/article/10.1007/BF02587914 I actually touched on this in more depth in a January post. Brain cancer doesn’t like DHA. Please read the whole post and bullet points to fully understand this.:  http://mybraincancerstory.blogspot.co.uk/2016/01/dha-more-important-than-ketones-for.html?m=1 The study I am currently critically analysing and has gained so much attention is this one below. I feel many people have been mislead by the findings so I will attempt to clear this up.  I think it’s a great study as it validates my approach, but I don’t agree that all fats are created equal. This study analysed linoleic acid in vivo. The results were interesting to me, but not particularly surprising. I don’t agree with the title or conclusions because I don’t agree that all fats are created equal, the type and ratio are of critical importance. I completely agree that this is true under the conditions applied in the study. I really like the study, I just don’t value the irresponsible conclusions made by journalists. I have access to the full study but this is the abstract: Fatty acid oxidation is required for the respiration and…

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Flummoxed- Day 3 of BNOS 2016

Focus for HIF-1 is radiation and temozolomide in rodents. I asked about HBOT, even with temozolomide, not even considered but seems obvious to me.  I also asked if it could be replicated in the rodent model and if it could be predicted that it may potentially further exploit this hypoxia in the GBM cells. This part of my question wasn’t really answered.  Hyperbaric oxygen therapy works in similar fashion to radiotherapy by inducing oxidative stress but without ionising radiation so I wonder why this isn’t applied to rodent models often. Perhaps it is a funding issue, I know it’s possible but I have seen very few studies on this. There is so much potential with HBOT. It was a great talk, lots of information but I feel more could be done.  Am I missing something?

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