Focus for HIF-1 is radiation and temozolomide in rodents. I asked about HBOT, even with temozolomide, not even considered but seems obvious to me.
I also asked if it could be replicated in the rodent model and if it could be predicted that it may potentially further exploit this hypoxia in the GBM cells. This part of my question wasn’t really answered.
Hyperbaric oxygen therapy works in similar fashion to radiotherapy by inducing oxidative stress but without ionising radiation so I wonder why this isn’t applied to rodent models often. Perhaps it is a funding issue, I know it’s possible but I have seen very few studies on this. There is so much potential with HBOT. It was a great talk, lots of information but I feel more could be done.
Am I missing something?