Latest

Whatever Intro

An introductory section, can be absolutely anything. Edit in Appearance>Theme Control Panel>Blog>Welcome Block. Can be removed.

About Me

My Story

Resource

Brain Cancer Options

My Channel

View videos

Podcasts

Beating Brain Cancer

Forum

Join

CUSP-ND

Support Research
Uncategorized

Flummoxed- Day 3 of BNOS 2016

Focus for HIF-1 is radiation and temozolomide in rodents. I asked about HBOT, even with temozolomide, not even considered but seems obvious to me.  I also asked if it could be replicated in the rodent model and if it could be predicted that it may potentially further exploit this hypoxia in the GBM cells. This part of my question wasn’t really answered.  Hyperbaric oxygen therapy works in similar fashion to radiotherapy by inducing oxidative stress but without ionising radiation so I wonder why this isn’t applied to rodent models often. Perhaps it is a funding issue, I know it’s possible but I have seen very few studies on this. There is so much potential with HBOT. It was a great talk, lots of information but I feel more could be done.  Am I missing something?

Continue reading
Uncategorized

BNOS Conference 2016- My thoughts on Day 1

Yesterday I awoke bright and early, on my way to the University of Leeds for the British Neuro Oncology Society’s (BNOS) annual conference. This particular conference is titled; ‘Trials, Technologies and T Cells.’ I will be attending for the duration, 3 days, whereby I will hear from a number of influential speakers in the field. I feel I am in a fortunate position to be able to peer beyond that no so transparent screen between the patient and scientist understanding and experience of this disease. Bridging that gap and relaying important information and experiences to and from both sides is of great importance to me. I feel a great sense of responsibility to represent these patients as best I can and vice versa.  I had been looking forward to seeing some of the latest research developments, particularly relating to recent developments in immunotherapy, novel new imaging techniques, and also the latest research from Imperial College London (with whom I am travelling) on the ketogenic diet studied in vitro using ketone esters. I will be in their research lab very soon to test some of my own theories barring any possible restrictions I may encounter. The main objective of BNOS is to ‘promote research and education in Neuro-Oncology and to improve treatment of patients with tumours of the central nervous system.’ I was very much looking forward to hearing presentations from speakers coming to Leeds from around the world. The conference themes are: – Genomics – Glioma Biology – Imaging Radiotherapy and Surgical Technologies – Immunotherapy – Novel Technologies – Brain Metastases – Clinical Studies I will try to update as much as I can through my blog and social media as the conference progresses with new information I take in along with my thoughts. I had been especially interested in…

Continue reading
Uncategorized

Sunbathing- Heliotherapy and grounding

To the people laughing at me sunbathing practically naked in the park- my health is worth more than your opinions.  Vitamin D and light is king, don’t waste this precious sunlight. Supplemental vitamin D does not compare, it is not a vitamin, it’s a hormone that is synthesised from UV light onto the skin and we need the full spectrum.  In the UK we don’t get much sun so you have to take every opportunity to get it while you can. I occasionally use special sunbeds (during a week of bad weather) that have the right ratio of UVA and UVB for my skin- it’s personalised and actually protects against many cancers, contrary to popular belief. If you use a standard sunbed this is not the same and can be very harmful, especially if used frequently. I only go once a week and only when the weather is terrible.  I also now never wear sunglasses as I understand UV light going into the retina is very important for not just eye health but overall health. I won’t look directly at the sun, but make efforts to look in the direction of it. You can actually become more photosensitive if you wear sunglasses and may end up like Bono. This is why I will never wear sunglasses, and only blue blockers in artificial light at appropriate times.  http://jbr.sagepub.com/content/31/3/223.short My first choice will always be to lie in the sun, on the ground and with my skin in contact with the ground. In future I’m looking to move to somewhere with more sun, less population, and less nnEMF, preferably none or next to nothing! Studies on constantly being exposed to EMF are inconclusive but it’s something that is very difficult to prove either way. It makes sense to me to have breaks…

Continue reading
Uncategorized

Visit to the holistic dentist- its been a long time coming…

I just had an interesting meeting at the dentist, The news I received wasn’t surprising considering I had been meaning to remove two fillings in my mouth for a while. The whole situation left me quite upset, knowing that this situation is not unusual. I have 2 amalgam fillings that I have had for years and I know that mercury toxicity can be a causative factor for ‘brain fog’ and a contributory factor for several neurological conditions and diseases.  Some background research showing why this visit is so important for my long term health: ‘Unpolymerized resin (co)monomers or mercury (Hg) can be released from restorative dental materials (e.g. composites and amalgam). They can diffuse into the tooth pulp or the gingiva. They can also reach the gingiva and organs by the circulating blood after the uptake from swallowed saliva.’ http://link.springer.com/article/10.1007/s00204-006-0073-5 ‘Mercury exerts a variety of toxic effects on both neurons and glia and also may play a role in patho- physiological mechanisms of Alzheimer’ s disease in neuroblastoma cells. Studies in vivo and in vitro have shown that mer- cury generates reactive oxygen species (ROS) and lipid peroxidation in brain tissues, suggesting that the cell injury induced by ROS, including super- oxide anion, hydrogen peroxide, hydroxyl radical, and peroxynitrite, may contribute to the development of neurodegenerative disorders caused by mercury intox- ication.’ http://link.springer.com/article/10.1023/A:1013955020515 I was deeply concerned with how I wasn’t able to have this removal much earlier after my cancer diagnosis. I had experienced significant apprehension over a period of time about the thought of seeing a ’normal’ dentist. I had actually given in and saw one eventually, but they were adamant that it would be best to leave the fillings, informing me that it would actually be more of a risk to remove them, exposing myself to more of the…

Continue reading
Uncategorized

I’m afraid of heights but I did it!

It was challenging but well worth it. Thank you so much for all of your support and donations, I’m in awe of how much has been raised in such a short space of time. This money will go directly into research and if you would like more specific details I’m sure Brain Tumour Research would be more than happy to explain where the money is going.  This is no ordinary cancer charity, they are quickly becoming like a family to me in how they are supporting both me as an individual and my metabolic approach to my individual situation. The work they are doing makes me so excited about the future because I believe that this way of treating cancer is the future and should be the present.I know they are working very hard to make this a reality as soon as possible so I found my experience today incredibly satisfying with that in mind despite my fear of heights. It personified my journey in a way, a mini triumph over adversity and tough challenges, but there is a long way to go (its not just about me) and people who support me have played a huge part in that journey. Thank you once again, the support is overwhelming and I am incredibly grateful. I know the many patients and their families who are currently suffering from this disease or who have had loved ones taken away too soon will also be thankful. I believe we are taking steps closer to making this a thing of the past and for changing how we treat not only brain cancer but all cancers.

Continue reading
Uncategorized

Very short notice- 3 year Cancerversary celebrations!

Very short notice but as part of my 3 year Cancerversary celebrations and to celebrate my last scan showing no disease and further improvement of scar tissue on MR spectroscopy I will be doing an abseil down the iconic Spinnaker Tower in Portsmouth in aid of Brain Tumour Research. I am incredibly passionate about the work they do and 100% of the money received by the charity goes directly into vital research. I have over 1,000 friends on Facebook, if everybody gives just £1 Brain Tumour Research will receive £1,000. I also nearly have 50,000 viewers of this blog which blows my mind but also thinks I can make a real difference to getting this promising research out there so it can eventually replace the standard treatment for brain cancer in time. This is what I firmly believe. I guarantee that no money will be wasted and it is for a worthwhile cause. In addition I will be organising my own events to raise funds and celebrate my 3 year Cancerversary over the next few weeks in various locations. It has been 3 years since my diagnosis. They couldn’t remove the whole tumour but I have recently achieved my most promising scan yet showing no disease on MR Spectroscopy. It is also worth noting that many other cancers become terminal once they spread to the brain so this work is of great importance to how we treat all cancers to improve prognosis and in future find a cure. We need money to fund clinical trials for these non toxic approaches that show so much promise so that patients don’t have to use themselves as human guinea pigs without knowing what they are doing. Please give what you can, I’ll try not to kill myself leaping off the edge of the…

Continue reading
Uncategorized

Meeting my heroes and learning about exciting developments- clomipramine and the ketogenic diet.

Brain Tumour Research is one of the few charities I know that supports the metabolic approach to managing cancer through the use of novel agents and dietary intervention. Ever since I moved from The Royal Marsden to Charing Cross Hospital I have had continued support and encouragement which was previously lacking. This is the type of resistance I continually experienced 3 years ago but I soldiered on regardless, believing in what I was doing from the countless hours of research I had undertaken. I showed them all my research but they didn’t want to change their opinion. I saw 5 different neurologists who all gave me the same responses. I’ve been off medication for a long time now despite being told I would need to be on it for life. The move was truly liberating for me and I have worked incredibly hard to achieve the success that I have had over the last 3 years. It makes me emotional at times and on the verge of tears as I recall the resistance I initially experienced from various health professionals and then think about the incredible successes I experienced over the last 3 years both on scans and symptomatically. Experimenting and researching on your own when you are experiencing horrible seizures and debilitating symptoms daily tested my resolve and my conviction several times over this period. After my mother was diagnosed with oesophageal cancer not long after my diagnosis as a consequence of her osteoperosis medication (we were actually able to prove this!) my resolve was tested further. She never smoked and seldomly drank alcohol, when she did it was simply a small glass of red wine. She has always been a picture of health and has followed a healthy lifestyle. Upon diagnosis of her cancer we asked about the…

Continue reading
Uncategorized

Clock genes, chronotherapy, exogenous ketones, MRI scans

I filmed this last week, taking some time out of my pharmacology revision to talk about chronotherapy. I still have a lot to learn but I’m really trying to get to grips with this approach in order to apply all of the theories appropriately. I described some of the adaptations I have made over the last couple of weeks to an important aspect of my metabolic approach, using myself as a reluctant human guinea pig as always. I will do anything to achieve the best result possible, however that represents itself. If all this sounds confusing I would thoroughly suggest giving this consice article a good read! https://www.roswellpark.org/cancertalk/201509/coordinating-cancer-treatment-your-inner-clock Clock genes in the brain can be powerful therapeutic tools we can exploit with chronotherapy. IMG- http://lightawake.com/understanding_blue.php Some methods described: The main thing I do is to supplement with exogenous ketones through habitual junctures consistent with theories I have predicted would present a chronotherapeutic benefit- ordinarily this is when the stress hormone cortisol rises to wake me up in the morning and then subsequently adrenaline rises (between 10am and 2pm for me as an individual- this is variable of course, biochemical individuality). Fig 1 provides an example we could use to display this idea for my type of epilepsy, ‘reflex epilepsy’. Fig 2 displays hormonal fluctuations in a typical sleep-wake cycle with natural light cycles. Fig 1: IMG- http://brain.oxfordjournals.org/content/early/2016/03/31/brain.aww071.figures-only   IMG- http://hompes-method.com/testing-toolkit/adrenal-stress-hormone-testing-cortisol-and-dhea/ I also use exogenous ketones with food when I am re-feeding after a therapeutic fast to mitigate the upsurge of growth factors that may occur as the body begins to metabolise food once more. I will often combine use of exogenous ketones with apple cider vinegar, high dose DHA fish oil gel tabs, and curcumin as I believe they could have a symbiotic benefit. DHA complements ketogenesis and curcumin improved uptake of DHA…

Continue reading
Uncategorized

Promoting autophagy with the aid of periodic, habitual therapeutic fasting for brain cancer management

I am inclined to conclude that the studies presented here in relation to fasting and autophagy provide sufficient evidence to support a key aspect of my metabolic strategy to manage brain cancer.... and no, its not just because I am biased. ;-) I have been experimenting with personalised fasting protocols lately, allowing for what I feel could be a theoretically viable symbiotic relationship of periodic, habitual therapeutic fasting + complimentary dose specific supplementation of fish oils + salt preparations + magnesium chloride supplementation as a specific, targeted, individualistic approach. I base this approach on my exhaustive research undertaken over the years following my diagnosis, scrutinising decades of evidence based, peer reviewed research to falsify or validate my hypotheses. I will attempt to explain why and how I believe implementation of such an approach could yield positive results for my n=1 experiment: Numerous individuals have queried my dietary protocol, however it could reasonably be postulated, based on the evidence and underlying physiological mechanisms of this type of dietary manipulation, that the most significant benefits would likely come from calorie restriction and fasting. The metabolic state prior to commencement of a fast and personal dietary choices upon completion of such endeavours are undoubtedly of vital importance of course so as to not raise IGF-1 and upregulate mTOR during the re-feeding phase. The gut microbiota before, during, and after fasting is another subject of great interest to me but I won't go into that because it is fairly complicated territory to cross over and I don't have time to talk about the trillions of bacteria involved despite it being critical to all aspects of health and all life on this planet as we know it... primordial poop and all that jazz. Back to autophagy, fasting, and re-feeding.... Growth factors must be regulated via continued... Continue reading
Uncategorized

More thoughts, experiments and investigations on curcumin in vivo

Following on from my last post, I have been questioning myself more about optimal dosages for supplementation of curcumin, particularly in light of such studies whereby ‘high’ amounts of the compound are tolerated with minimal to zero toxicity reported. One particular study caught my eye. ‘A dose escalation study was conducted to determine the maximum tolerated dose and safety of a single dose of standardized powder extract, uniformly milled curcumin (C3 Complex™, Sabinsa Corporation). Healthy volunteers were administered escalating doses from 500 to 12,000 mg.’ http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-6-1012,000 mg is a lot considering I take 1,500 mg per day which I deem to be the optimal therapeutic dose for me as an individual. There may be situations by which higher doses may be more beneficial though I believe the dosages I maintain at the moment should be adequate for my current aims. The results of the study revealed some thought provoking findings though I dd wonder about the 17 participants that did experience issues:‘Seven of twenty-four subjects (30%) experienced only minimal toxicity that did not appear to be dose-related. No curcumin was detected in the serum of subjects administered 500, 1,000, 2,000, 4,000, 6,000 or 8,000 mg. Low levels of curcumin were detected in two subjects administered 10,000 or 12,000 mg.’The study goes on to say that ‘no toxicity appeared to be dose related’, indicating that of those 17 participants there may have been extraneous factors or sensitivities to the curcuminoid formulation regardless of the dose ingested. I also believe that because the trial was looking at a single, oral dose of this formulation, it may have been enough to explain some of these mild, adverse effects. Nevertheless, they concluded that ,’The tolerance of curcumin in high single oral doses appears to be excellent.’ Given the relatively very high doses used in the study on the whole…

Continue reading
Close